... Philip1
Email: nsp@stthom.ernet.in 
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...-cells2
It is hypothesised that when insulin resistance occurs, in its chase for producing a surge supply of insulin to compensate for the increase is glucose in the blood stream, the $\beta$-cells weakens down and causes type 2 diabetes. 
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... drugs3
Research in obesity resulted in the identification of some of the molecular switches (nuclear transcriptional factors) that play a central role in determining how fat cells (adipocytes) develop. One of these molecules called PPAR (Peroxisome Proliferator Activating Receptor) functions as the receptor for the insulin-sensitizing drug Thiazolidinediones. 
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... phenomena4
Measurement of insulin resistance using insulin clamp studies is technically difficult, and not a suitable technique for large scale epidemiologic studies. 
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